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Tirzepatide 5 mg Tirzepatide 10 mg Tirzepatide 15 mg Placebo

A1C reduction from baseline of 7.9%

Tirzepatide 5 mg:

-1.87%

Tirzepatide 10 mg:

-1.89%

Tirzepatide 15 mg:

-2.07%

Placebo:

+0.04%

Placebo-adjusted A1C reduction

Tirzepatide 5 mg:

-1.91%

Tirzepatide 10 mg:

-1.93%

Tirzepatide 15 mg:

-2.11%

Placebo:

N/A

Weight reduction from baseline of 85.9 kg

Tirzepatide 5 mg:

-7.0 kg (-7.9%)

Tirzepatide 10 mg:

-7.8 kg (-9.3%)

Tirzepatide 15 mg:

-9.5 kg (-11.0%)

Placebo:

-0.7 kg (-0.9%)

Placebo-adjusted weight reduction

Tirzepatide 5 mg:

-6.3 kg

Tirzepatide 10 mg:

-7.1 kg

Tirzepatide 15 mg:

-8.8 kg

Placebo:

N/A

Percent of participants achieving A1C <7%

Tirzepatide 5 mg:

86.8%

Tirzepatide 10 mg:

91.5%

Tirzepatide 15 mg:

87.9%

Placebo:

19.6%

Percent of participants achieving A1C <5.7%

Tirzepatide 5 mg:

33.9%

Tirzepatide 10 mg:

30.5%

Tirzepatide 15 mg:

51.7%

Placebo:

0.9%

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